The Brazil 2021 COVID-19 Phone Survey was conducted to provide information on how the pandemic had been affecting Brazilian households in 2021. It was inspired by the Latin America and Caribbean High Frequency Phone Surveys and collected information along multiple dimensions relevant to the welfare of the population (e.g. changes in employment and income, coping mechanisms, access to health and education services, gender inequalities, and food insecurity). A total of 2,166 phone interviews were conducted across all Brazilian states between July 26 and October 1, 2021. The survey followed a Random Digit Dialing (RDD) sampling methodology using a dual sampling frame of cellphone and landline numbers. The sampling frame was stratified by type of phone and state. Results are nationally representative for households with a landline or at least one cell phone and of individuals of ages 18 years and above who have an active cell phone number or a landline at home.